Acta Physica Polonica B

Vol. 36, No. 5, May 2005, page 1791


Polypeptide Translocation Through a Hole. A Monte Carlo Study

A. Sikorski, P. Romiszowski

In this work we studied a simple model of a copolymer (polypeptide) chain in a confined space. The model chain was restricted to a flexible [310] lattice. It was represented as a sequence of united atoms located at the positions of alpha carbons. The force field introduced into the model consisted of the long-range contact potential between amino acid residues and a local helical potential. The chain was built of hydrophilic and hydrophobic segments. The properties of such chains were determined by means of the Monte Carlo simulations using a Metropolis-like algorithm. During the simulations we observed and tracked the translocation of the chain during its passage through a hole in an impenetrable wall. The influence of the length of the chain and the structure of the polymer film on the translocation process were investigated. The dynamic properties of the system such as the translocation time were also studied and discussed.

PACS numbers: 87.15.Aa, 61.25.Hq, 36.20.Ey



 
Table of Contents Back to Number 5 contents