Each biological molecular machine can be effectively considered a common chemochemical enzymatic machine occurring, however, in multitude rather than a few conformational substates distinguished by the conventional kinetics. The cases of the proton pump cytochrome bc₁ and the actomyosin motor are considered in some detail. In the steady state, a slow character of conformational transition dynamics causes the necessity of replacing conventional reaction rate constants by more sophisticated quantities, the mean first-passage times between some distinguished conformational substates of the machine. The most important results obtained for the flux-force dependence of the actomyosin motor are noted.

PACS numbers: 05.70.Ln, 87.15.He, 87.15.Rn, 87.16.Nn