In this article, based on the talk given at the Cracow Epiphany Conference on Astroparticle Physics, I discuss some of the opportunities provided by high-energy and ultra-high energy neutrino astronomy in probing particle physics beyond the standard model. Following a short summary of current and next generation experiments, I review the prospects for observations of high-energy neutrino interactions, searches for particle dark matter, and measurements of absolute neutrino masses, lifetimes and pseudo-Dirac mass splittings.

PACS numbers: 95.55.Vj, 96.40.-z