The effects of Coulomb and other charge-dependent interactions on the structure of nuclei are discussed. First, a method to predict absolute binding energies for proton-rich nuclei that allows a mapping of the proton drip-line up to A=70 is presented. Then the effects of isospin-symmetry breaking on tests of the standard model for the weak interaction are examined. The principal areas discussed are (1) superallowed Fermi beta decay, which provides a test of the conserved vector current hypothesis and the unitarity of Cabibbo--Kobayashi--Maskawa matrix; and (2) parity violation in electron scattering, which offers a window into the neutral-current sector of the weak interaction.

PACS numbers: 21.10.Dr, 21.10.Sf, 21.10.Tg, 23.40.Bw